Understanding Depression
How depression is diagnosed
Diagnosis begins with a clinical interview about mood, loss of interest, sleep, energy, concentration, appetite, guilt, thoughts of death, functioning, and the timeline of symptoms. Major depressive episodes generally involve at least five qualifying symptoms over the same two-week period, including depressed mood or loss of interest, with meaningful distress or impairment. Clinicians also assess safety, medications, substance use, medical contributors, and any past mania or hypomania.
The PHQ-2 and PHQ-9 can help screen for symptoms and monitor progress, but a questionnaire alone does not establish a diagnosis. AAFP: Depression Screening and Diagnosis →
Sadness, grief, and depression
Sadness is a normal human emotion that may come and go in response to life events. Grief is a response to loss and often arrives in waves, with memories and moments of connection alongside pain. Major depression more often brings persistent depressed mood or diminished interest, broad changes in thinking and physical functioning, and significant impairment. Grief and depression can coexist; grief does not rule out major depression. The assessment considers context, duration, pervasiveness, and safety rather than assuming any response to loss is pathological.
Common Medications for Depression
Review an educational table of frequently used medication classes, examples, and clinical considerations.
Explore the Medication Table →PHQ-9: optional self-screen
This validated questionnaire asks about symptoms over the last 2 weeks. It can help start a discussion; the result is not a diagnosis. Responses remain in your browser—this page does not send them to EvolveMD.
PHQ-9 questionnaire
Over the last two weeks, how often have you been bothered by the following problems?
If you endorse thoughts of death or self-harm, contact a healthcare professional promptly regardless of your total score. If you may act on those thoughts or are in immediate danger, call 911 or go to an emergency department; in the U.S., call or text 988 for crisis support.
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